Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study

Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study

Abstract Background Septic shock is a life-threatening condition that challenges immune cells to reprogram their mitochondrial metabolism towards to increase ATP synthesis for building an appropriate immunity. This could print metabolic signatures in mitochondria whose association with disease progr...

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Bibliographic Details
Main Authors: Wagner Luis Nedel, Afonso Kopczynski, Marcelo Salimen Rodolphi, Nathan Ryzewski Strogulski, Marco De Bastiani, Tiago Hermes Maeso Montes, Jose Abruzzi Jr, Antonio Galina, Tamas L. Horvath, Luis Valmor Portela
Format: Article
Language:English
Published: SpringerOpen 2021-07-01
Series:Intensive Care Medicine Experimental
Subjects:
Septic shock
Lymphocytes
Mitochondrial signatures
Mortality
Prognostic biomarker
Online Access:https://doi.org/10.1186/s40635-021-00404-9

Internet

https://doi.org/10.1186/s40635-021-00404-9

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