Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer.

Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer.

Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC). The aim of this study was to evaluate the epigenetic silencing of RPRM gene by p...

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Bibliographic Details
Main Authors: Kathleen Saavedra, José Valbuena, Wilda Olivares, María José Marchant, Andrés Rodríguez, Verónica Torres-Estay, Gonzalo Carrasco-Avino, Leda Guzmán, Francisco Aguayo, Juan Carlos Roa, Alejandro H Corvalán
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4425545?pdf=render

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http://europepmc.org/articles/PMC4425545?pdf=render

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