Mutational effects of Cys113 on structural dynamics of Pin1
Pin1 is a peptidyl-prolyl isomerase (PPIase) which catalyzes cis/trans isomerization of pS/pT-P bond. Its activity is related to various cellular functions including suppression of Alzheimer’s disease. A cysteine residue C113 is known to be important for its PPIase activity; a mutation C113A reduced...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Biophysical Society of Japan
2019-11-01
|
| Series: | Biophysics and Physicobiology |
| Subjects: | |
| Online Access: | https://doi.org/10.2142/biophysico.16.0_452 |