Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults

Resting-State Functional Connectivity Is Associated With Cerebrospinal Fluid Levels of the Synaptic Protein NPTX2 in Non-demented Older Adults

Intrinsic functional connectivity of large-scale brain networks has been shown to change with aging and Alzheimer’s disease (AD). These alterations are thought to reflect changes in synaptic function, but the underlying biological mechanisms are poorly understood. This study examined whether Neurona...

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Bibliographic Details
Main Authors: Anja Soldan, Abhay Moghekar, Keenan A. Walker, Corinne Pettigrew, Xirui Hou, Hanzhang Lu, Michael I. Miller, Alfonso Alfini, Marilyn Albert, Desheng Xu, Mei-Fang Xiao, Paul Worley, The BIOCARD Research Team, John Csernansky, David Holtzman, David Knopman, Walter Kukull, Kevin Grimm, John Hsiao, Laurie Ryan, Constantine Lyketsos, Carlos Pardo, Gerard Schellenberg, Leslie Shaw, Madhav Thambisetty, John Trojanowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
resting-state functional connectivity
magnetic resonance imaging
cerebrospinal fluid
NPTX2
synaptic function
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00132/full

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https://www.frontiersin.org/article/10.3389/fnagi.2019.00132/full

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