Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.

Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation. These AAs induce translocation of mTOR to late endosomes and lysosomes (LELs), subseq...

Full description

Bibliographic Details
Main Authors: Margrét H Ögmundsdóttir, Sabine Heublein, Shubana Kazi, Bruno Reynolds, Shivanthy M Visvalingam, Michael K Shaw, Deborah C I Goberdhan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3344915?pdf=render

Internet

http://europepmc.org/articles/PMC3344915?pdf=render

Similar Items