On the viability of <it>Escherichia coli </it>cells lacking DNA topoisomerase I

<p>Abstract</p> <p>Background</p> <p>Manipulations of the DNA double helix during replication, transcription and other nucleic acid processing cause a change of DNA topology, which results in torsional stress. This stress is relaxed by DNA topoisomerases, a class of enz...

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Bibliographic Details
Main Authors: Stockum Anna, Lloyd Robert G, Rudolph Christian J
Format: Article
Language:English
Published: BMC 2012-02-01
Series:BMC Microbiology
Online Access:http://www.biomedcentral.com/1471-2180/12/26