Hybrid Stem Cell States: Insights Into the Relationship Between Mammary Development and Breast Cancer Using Single-Cell Transcriptomics

Hybrid Stem Cell States: Insights Into the Relationship Between Mammary Development and Breast Cancer Using Single-Cell Transcriptomics

Similarities between stem cells and cancer cells have implicated mammary stem cells in breast carcinogenesis. Recent evidence suggests that normal breast stem cells exist in multiple phenotypic states: epithelial, mesenchymal, and hybrid epithelial/mesenchymal (E/M). Hybrid E/M cells in particular h...

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Bibliographic Details
Main Authors: Tasha Thong, Yutong Wang, Michael D. Brooks, Christopher T. Lee, Clayton Scott, Laura Balzano, Max S. Wicha, Justin A. Colacino
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
stem cells
breast cancer
single-cell RNA sequencing
hybrid
epithelial
mesenchymal
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00288/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00288/full

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