Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

A primary target of the pleiotropic metabolic hormone FGF21 is adipose tissue, where it initiates a gene expression program to enhance energy expenditure, an effect presumed to be centered on augmented UCP1 expression and activity. In UCP1 null (UCP1KO) mice, we show that the effect of FGF21 to incr...

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Bibliographic Details
Main Authors: Ricardo J. Samms, Dennis P. Smith, Christine C. Cheng, Patrick P. Antonellis, James W. Perfield 2nd, Alexei Kharitonenkov, Ruth E. Gimeno, Andrew C. Adams
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715004635

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http://www.sciencedirect.com/science/article/pii/S2211124715004635

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