Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells

Amyloid β-Induced Redistribution of Transcriptional Factor EB and Lysosomal Dysfunction in Primary Microglial Cells

Impaired clearance of Amyloid β (Aβ) by microglia in the brain may be associated with the senile plaque formation, a pathological hallmark relevant to Alzheimer's disease. Microglial cells in the brain are not able to efficiently degrade Aβ, suggesting that microglial lysosome impairment may oc...

Full description

Bibliographic Details
Main Authors: Xingzhi Guo, Peng Tang, Li Chen, Peng Liu, Chen Hou, Xin Zhang, Yue Liu, Li Chong, Xiaoqing Li, Rui Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Aging Neuroscience
Subjects:
microglia
amyloid
degradation
TFEB
lysosome
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00228/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00228/full

Similar Items