Active immunization with GnRH-tandem-dimer peptide in young male rats reduces serum reproductive hormone concentrations, testicular development and spermatogenesis

Active immunization with GnRH-tandem-dimer peptide in young male rats reduces serum reproductive hormone concentrations, testicular development and spermatogenesis

GnRH sterilization vaccines have been developed for various practical and clinical reasons. However, conjugation of GnRH peptide to carrier protein has many drawbacks, hampering the further commercialization of GnRH vaccines. In this study, a new nonconjugated GnRH vaccine, D-Lys6-GnRH-tandem-dimer...

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Bibliographic Details
Main Authors: Xing-Fa Han, Jun-Li Li, Yu-Qin Zhou, Xiao-Hua Ren, Gong-Cheng Liu, Xiao-Han Cao, Xiao-Gang Du, Xian-Yin Zeng
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Asian Journal of Andrology
Subjects:
GnRH; nonconjugation; rat; reproductive axis; sterilization
Online Access:http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=3;spage=485;epage=491;aulast=Han

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http://www.ajandrology.com/article.asp?issn=1008-682X;year=2016;volume=18;issue=3;spage=485;epage=491;aulast=Han

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