Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons

Functional constraints on the constitutive androstane receptor inferred from human sequence variation and cross-species comparisons

<p>Abstract</p> <p>Members of the NR1I subfamily of nuclear receptors play a role in the transcriptional activation of genes involved in drug metabolism and transport. NR1I3, the constitutive androstane receptor (CAR), mediates the induction of several genes involved in drug respon...

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Bibliographic Details
Main Authors: Thompson Emma E, Kuttab-Boulos Hala, Krasowski Matthew D, Di Rienzo Anna
Format: Article
Language:English
Published: BMC 2005-09-01
Series:Human Genomics
Subjects:
pharmacogenetics
nuclear receptors
haplotype structure
sequence variation
Online Access:http://www.humgenomics.com/content/2/3/168

Internet

http://www.humgenomics.com/content/2/3/168

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