ACTH Prevents Deficits in Fear Extinction Associated with Early Life Seizures

Early life seizures are often associated with cognitive and psychiatric comorbidities that are detrimental to quality of life. In a rat model of early life seizures (ELS), we explored long-term cognitive outcomes in adult rats. Using ACTH, an endogeneous HPA-axis hormone given to children with sever...

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Bibliographic Details
Main Authors: Andrew T Massey, David K Lerner, Gregory L Holmes, Rod C Scott, Amanda Erin Hernan
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Neurology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2016.00065/full