Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Abstract Background Mast cells (MCs), the ‘first responders’ in brain injury, are able to disrupt the blood–brain barrier (BBB), but the underlying mechanism is not well understood. Tryptase is the most abundant MC secretory product. Protease-activated receptor 2 (PAR-2) has been identified as a spe...

Full description

Bibliographic Details
Main Authors:	Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong, Yan-ning Qian
Format:	Article
Language:	English
Published:	BMC 2018-08-01
Series:	Journal of Neuroinflammation
Subjects:	Brain microvascular endothelial cells Tryptase Protease-activated receptor 2 (PAR-2) MAPK NF-kappa B
Online Access:	http://link.springer.com/article/10.1186/s12974-018-1287-1

Similar Items

Mast cells positive to tryptase, endothelial cells positive to protease-activated receptor-2, and microvascular density correlate among themselves in hepatocellular carcinoma patients who have undergone surgery
by: Ammendola M, et al.
Published: (2016-07-01)

Up-regulation of COX-2/PGE<sub>2</sub> by endothelin-1 via MAPK-dependent NF-κB pathway in mouse brain microvascular endothelial cells
by: Lin Chih-Chung, et al.
Published: (2013-01-01)

Mast Cells Positive for c-Kit Receptor and Tryptase Correlate with Angiogenesis in Cancerous and Adjacent Normal Pancreatic Tissue
by: Michele Ammendola, et al.
Published: (2021-02-01)

Nociceptive Sensitization by Activation of Protease-Activated Receptor 2 in a Rat Model of Incisional Pain
by: Kanta Kido, et al.
Published: (2021-01-01)

Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2
by: Mariam Bagher, et al.
Published: (2018-09-01)

Mast cell tryptase enhances wound healing by promoting migration in human bronchial epithelial cells
by: Sofia Mogren, et al.
Published: (2021-01-01)

Tumor-Associated Macrophages and Mast Cells Positive to Tryptase Are Correlated with Angiogenesis in Surgically-Treated Gastric Cancer Patients
by: Giuseppe Sammarco, et al.
Published: (2018-04-01)

Increased TPSAB1 Copy Number in a Family With Elevated Basal Serum Levels of Tryptase
by: Laura Hernández-Hernández, et al.
Published: (2021-04-01)

Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity
by: Zhirong Fu, et al.
Published: (2019-10-01)

Protease-activated receptors and inflammatory hyperalgesia
by: Nathalie Vergnolle
Published: (2005-03-01)

Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study
by: Alexandre Denadai-Souza, et al.
Published: (2017-06-01)

Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1
by: Elín I. Magnúsdóttir, et al.
Published: (2020-04-01)

Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA
by: Sultan Alanazi, et al.
Published: (2020-07-01)

Tryptase as a marker of severity of aortic valve stenosis
by: Laura M. Losappio, et al.
Published: (2018-08-01)

Mouse Tryptase Gene Expression is Coordinately Regulated by GATA1 and GATA2 in Bone Marrow-Derived Mast Cells
by: Kinuko Ohneda, et al.
Published: (2019-09-01)

The effects of Secondhand Smoke (SHS) exposure on microvascular endothelial function among healthy women
by: Zulkefli Sanip, et al.
Published: (2015-09-01)

ROLE OF SERUM EOSINOPHILIC CATIONIC PROTEIN AND TRYPTASE IN MYELOPROLIFERATIVE AND LYMPHOPROLIFERATIVE DISORDERS
by: L. S. Komarova, et al.
Published: (2014-07-01)

Liver tryptase-positive mast cells and fibrosis in children with hepatic echinococcosis
by: Gulubova Maya, et al.
Published: (2005-01-01)

Mast Cell Proteases Tryptase and Chymase Induce Migratory and Morphological Alterations in Bronchial Epithelial Cells
by: Frida Berlin, et al.
Published: (2021-05-01)

Correlation of vascular endothelial growth factor and microvascular damage in diabetic retinopathy
by: Ji-Quan Wen, et al.
Published: (2015-12-01)

A fine balance between life and death: modulation of BCL-2 family members by Toxoplasma gondii
by: Gustavo eArrizabalaga
Published: (2011-03-01)

Hematopoietic Serine Proteases from the Mast Cell Chymase and Tryptase Loci - a Functional and Evolutionary Analysis
by: Reimer, Jenny
Published: (2008)

Genetic Regulation of Tryptase Production and Clinical Impact: Hereditary Alpha Tryptasemia, Mastocytosis and Beyond
by: Bettina Sprinzl, et al.
Published: (2021-02-01)

The role of serum tryptase in the diagnosis and monitoring of pediatric mastocytosis: a single-center experience
by: Magdalena Lange, et al.
Published: (2017-08-01)

Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses
by: Sangeetha Ramu, et al.
Published: (2021-06-01)

SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob−/− mice
by: Damilola D. Adingupu, et al.
Published: (2019-02-01)

Baicalin Induces IFN-α/β and IFN-γ Expressions in Cultured Mouse Pulmonary Microvascular Endothelial Cells
by: Ge HU, et al.
Published: (2012-04-01)

Research progress on the molecular mechanism of coronary microvascular endothelial cell dysfunction
by: Jianying Deng
Published: (2021-06-01)

Autophagy activation and the mechanism of retinal microvascular endothelial cells in hypoxia
by: Rong Li, et al.
Published: (2018-04-01)

Effect of platelet microvesicles on the function of human microvascular endothelial cells
by: PAN Lina, et al.
Published: (2020-04-01)

Stimulated mast cells promote maturation of myocardial microvascular endothelial cell neovessels by modulating the angiopoietin-Tie-2 signaling pathway
by: Z.H. Wang, et al.
Published: (2013-11-01)

Tryptase- and ghrelin positive mast cells in the interalveolar septa of rat’s lung
by: I. Ivanova, et al.
Published: (2021-12-01)

The release of tryptase from mast cells promote tumor cell metastasis via exosomes
by: Hui Xiao, et al.
Published: (2019-10-01)

Increase in Tryptase and Its Role in the Synovial Membrane of Overweight and Obese Patients with Osteoarthritis of the Knee
by: Takata K, et al.
Published: (2020-05-01)

Isolation, purification, and conditional immortalization of murine glomerular endothelial cells of microvascular phenotype
by: James F. Dylewski, et al.
Published: (2020-01-01)

Influenza A virus infects pulmonary microvascular endothelial cells leading to microvascular leakage and release of pro-inflammatory cytokines
by: Tiantian Han, et al.
Published: (2021-08-01)

Effects of Fullerenols on Mouse Brain Microvascular Endothelial Cells
by: Michael K. Schuhmann, et al.
Published: (2017-08-01)

Endothelial Progenitor Cell-Derived Microvesicles Promote Angiogenesis in Rat Brain Microvascular Endothelial Cells In vitro
by: Wen Zeng, et al.
Published: (2021-02-01)

The decrease of Tie-2 receptor phosphorylation in microvascular endothelial cells is involved in early brain injury after subarachnoid hemorrhage
by: Hua Gu, et al.
Published: (2018-08-01)

Skin tags: A link between lesional mast cell count/tryptase expression and obesity and dyslipidemia
by: Samar Abdallah M Salem, et al.
Published: (2013-01-01)