Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Abstract Background Mast cells (MCs), the ‘first responders’ in brain injury, are able to disrupt the blood–brain barrier (BBB), but the underlying mechanism is not well understood. Tryptase is the most abundant MC secretory product. Protease-activated receptor 2 (PAR-2) has been identified as a spe...

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Bibliographic Details
Main Authors: Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong, Yan-ning Qian
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Brain microvascular endothelial cells
Tryptase
Protease-activated receptor 2 (PAR-2)
MAPK
NF-kappa B
Online Access:http://link.springer.com/article/10.1186/s12974-018-1287-1

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http://link.springer.com/article/10.1186/s12974-018-1287-1

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