Iron as a Therapeutic Target in <i>HFE</i>-Related Hemochromatosis: Usual and Novel Aspects

Iron as a Therapeutic Target in <i>HFE</i>-Related Hemochromatosis: Usual and Novel Aspects

Genetic hemochromatosis is an iron overload disease that is mainly related to the <i>C282Y</i> mutation in the <i>HFE</i> gene. This gene controls the expression of hepcidin, a peptide secreted in plasma by the liver and regulates systemic iron distribution. Homozygous <i&...

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Bibliographic Details
Main Authors: Olivier Loréal, Thibault Cavey, François Robin, Moussa Kenawi, Pascal Guggenbuhl, Pierre Brissot
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Pharmaceuticals
Subjects:
iron
genetic hemochromatosis
non transferrin bound iron
hepcidin
ferroportin
venesections
Online Access:https://www.mdpi.com/1424-8247/11/4/131

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https://www.mdpi.com/1424-8247/11/4/131

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