Estimates of statistical significance for comparison of individual positions in multiple sequence alignments

<p>Abstract</p> <p>Background</p> <p>Profile-based analysis of multiple sequence alignments (MSA) allows for accurate comparison of protein families. Here, we address the problems of detecting statistically confident dissimilarities between (1) MSA position and a set of...

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Bibliographic Details
Main Authors: Sadreyev Ruslan I, Grishin Nick V
Format: Article
Language:English
Published: BMC 2004-08-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/5/106