High proportion of anergic B cells in the bone marrow defined phenotypically by CD21(−/low)/CD38- expression predicts poor survival in diffuse large B cell lymphoma

High proportion of anergic B cells in the bone marrow defined phenotypically by CD21(−/low)/CD38- expression predicts poor survival in diffuse large B cell lymphoma

Abstract Background Diffuse large B cell lymphoma (DLBCL) is the commonest lymphoma that is highly aggressive where one-third of the patients relapse despite effective treatment. Interaction between the lymphoma cells and the non-clonal immune cells within the bone marrow microenvironment is thought...

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Bibliographic Details
Main Authors: Sewa Rijal, Johanna Kok, Caitlin Coombes, Lillian Smyth, Jayde Hourigan, Sanjiv Jain, Dipti Talaulikar
Format: Article
Language:English
Published: BMC 2020-11-01
Series:BMC Cancer
Subjects:
Diffuse large B cell lymphoma
B cells
Prognosis
Microenvironment
Anergic
Online Access:http://link.springer.com/article/10.1186/s12885-020-07525-6

Internet

http://link.springer.com/article/10.1186/s12885-020-07525-6

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