Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures.

We investigated the sensitivity of intrahepatic cholangiocarcinoma (IHCCA) subtypes to chemotherapeutics and molecular targeted agents. Primary cultures of mucin- and mixed-IHCCA were prepared from surgical specimens (N. 18 IHCCA patients) and evaluated for cell proliferation (MTS assay) and apoptos...

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Main Authors: Alice Fraveto, Vincenzo Cardinale, Maria Consiglia Bragazzi, Felice Giuliante, Agostino Maria De Rose, Gian Luca Grazi, Chiara Napoletano, Rossella Semeraro, Anna Maria Lustri, Daniele Costantini, Lorenzo Nevi, Sabina Di Matteo, Anastasia Renzi, Guido Carpino, Eugenio Gaudio, Domenico Alvaro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4646673?pdf=render