Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig DH Gene Segment

Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig DH Gene Segment

We have previously shown that the sequence of the immunoglobulin diversity gene segment (DH) helps dictate the structure and composition of complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3). In order to test the role of germline D sequence on the diversity of the preimm...

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Bibliographic Details
Main Authors: Mohamed Khass, Michael Levinson, Robert L. Schelonka, Pratibha Kapoor, Peter D. Burrows, Harry W. Schroeder
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
germline
T cell receptor
gene segment
immunoglobulin
D gene segment
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02079/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02079/full

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