Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD+ Synthesis During Inflammation and Infection

Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD+ Synthesis During Inflammation and Infection

Quinolinate (Quin) is a classic example of a biochemical double-edged sword, acting as both essential metabolite and potent neurotoxin. Quin is an important metabolite in the kynurenine pathway of tryptophan catabolism leading to the de novo synthesis of nicotinamide adenine dinucleotide (NAD+). As...

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Bibliographic Details
Main Authors: John R. Moffett, Peethambaran Arun, Narayanan Puthillathu, Ranjini Vengilote, John A. Ives, Abdulla A-B Badawy, Aryan M. Namboodiri
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
quinolinic acid
indoleamine 2,3-dioxygenase
kynurenine pathway
PARP
cell motility
foam cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00031/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00031/full

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