Linkage Evidence for a Two-Locus Inheritance of LQT-Associated Seizures in a Multigenerational LQT Family With a Novel KCNQ1 Loss-of-Function Mutation

Linkage Evidence for a Two-Locus Inheritance of LQT-Associated Seizures in a Multigenerational LQT Family With a Novel KCNQ1 Loss-of-Function Mutation

Mutations in several genes encoding ion channels can cause the long-QT (LQT) syndrome with cardiac arrhythmias, syncope and sudden death. Recently, mutations in some of these genes were also identified to cause epileptic seizures in these patients, and the sudden unexplained death in epilepsy (SUDEP...

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Bibliographic Details
Main Authors: Harald Prüss, Guido Gessner, Stefan H. Heinemann, Franz Rüschendorf, Ann-Kathrin Ruppert, Herbert Schulz, Thomas Sander, Wilhelm Rimpau
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neurology
Subjects:
LQT syndrome
KCNQ1
familial epilepsy
risk haplotype
genetic modifier
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00648/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.00648/full

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