Trapping DNA Replication Origins from the Human Genome

Trapping DNA Replication Origins from the Human Genome

Synthesis of chromosomal DNA is initiated from multiple origins of replication in higher eukaryotes; however, little is known about these origins’ structures. We isolated the origin-derived nascent DNAs from a human repair-deficient cell line by blocking the replication forks near the origins using...

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Bibliographic Details
Main Authors: Fumio Hanaoka, Toshihiko Eki, Yasufumi Murakami
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Genes
Subjects:
DNA replication
replication origins
sequence analysis
human genome
competitive PCR
Online Access:http://www.mdpi.com/2073-4425/4/2/198

Internet

http://www.mdpi.com/2073-4425/4/2/198

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