Changes in functional coupling of 5-HT1A receptor to the G-protein in neocortex temporal tissues of patients with temporal lobe epilepsy

Background: The 5-hydroxytryptamine-1A receptors are known to be involved in the inhibition of seizures in epilepsy. Objective: The main aim of the present study is to determine the functional coupling to G-protein of the 5-HT1A receptor through 8-OH-DPAT-stimulated [35S]GTPγS binding assay in later...

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Main Authors: M. Cuellar-Herrera, L. Rocha, N. Saleh-Subaie, F. Velasco, G. Aguado-Carrillo, M. Alonso-Vanegas, R. Guevara-Guzmán, A.L. Velasco
Format: Article
Language:English
Published: Permanyer 2018-10-01
Series:Revista Médica del Hospital General de México
Online Access:http://www.sciencedirect.com/science/article/pii/S0185106318300398