Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily

Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily

Abstract Ligands of the transforming growth factor-β (TGF-β) superfamily are important targets for therapeutic intervention but present challenges because they signal combinatorially and exhibit overlapping activities in vivo. To obtain agents capable of sequestering multiple TGF-β superfamily ligan...

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Bibliographic Details
Main Authors: Ravindra Kumar, Asya V. Grinberg, Huiming Li, Tzu-Hsing Kuo, Dianne Sako, Lavanya Krishnan, Katia Liharska, Jia Li, Rosa Grenha, Michelle C. Maguire, Steven D. Briscoe, R. Scott Pearsall, Brantley R. Herrin, Rajasekhar N. V. S. Suragani, Roselyne Castonguay
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97203-9

Internet

https://doi.org/10.1038/s41598-021-97203-9

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