Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia

Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia

Lung injury associated with hyperoxia reflects in part the secondary effects of pulmonary inflammation and the associated production of reactive oxygen species due to activation of NADPH oxidase, type 2 (NOX2). Activation of NOX2 requires the phospholipase A2 (PLA2) activity of peroxiredoxin 6 (Prd...

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Bibliographic Details
Main Authors: Bavneet Benipal, Sheldon I. Feinstein, Shampa Chatterjee, Chandra Dodia, Aron B. Fisher
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Redox Biology
Subjects:
Acute lung injury
Oxidative stress
Lipid peroxidation
MJ33
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231715000129

Internet

http://www.sciencedirect.com/science/article/pii/S2213231715000129

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