Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging

Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging

The objective of this study was to investigate in vitro the interactions between novel epidermal growth factor receptor kinase inhibitors (EGFRIs) developed for positron emission tomography (PET) imaging and the major efflux transporter breast cancer resistance protein (BCRP/ABCG2). Seven compounds...

Full description

Bibliographic Details
Main Authors: Israa eAbdelrahman, Miriam eShmuel, Sara eEyal
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Pharmacology
Subjects:
P-Glycoprotein
imaging
Breast cancer resistance protein
epidermal growth factor receptor
Positron emission tomography.
epidermal growth factor receptor kinase inhibitors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00257/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00257/full

Similar Items