Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing

Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing

<p>Abstract</p> <p>Background</p> <p>Reduced representation bisulfite sequencing (RRBS) was developed to measure DNA methylation of high-CG regions at single base-pair resolution, and has been widely used because of its minimal DNA requirements and cost efficacy; howeve...

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Bibliographic Details
Main Authors: Wang Junwen, Xia Yudong, Li Lili, Gong Desheng, Yao Yu, Luo Huijuan, Lu Hanlin, Yi Na, Wu Honglong, Zhang Xiuqing, Tao Qian, Gao Fei
Format: Article
Language:English
Published: BMC 2013-01-01
Series:BMC Genomics
Subjects:
Single-enzyme RRBS
Double-enzyme RRBS
DNA methylation
CpG coverage
Online Access:http://www.biomedcentral.com/1471-2164/14/11

Internet

http://www.biomedcentral.com/1471-2164/14/11

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