Likelihood of Null Effects of Large NHLBI Clinical Trials Has Increased over Time.

We explore whether the number of null results in large National Heart Lung, and Blood Institute (NHLBI) funded trials has increased over time.We identified all large NHLBI supported RCTs between 1970 and 2012 evaluating drugs or dietary supplements for the treatment or prevention of cardiovascular d...

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Bibliographic Details
Main Authors: Robert M Kaplan, Veronica L Irvin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4526697?pdf=render