Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis

Deoxycholate, an Endogenous Cytotoxin/Genotoxin, Induces the Autophagic Stress-Survival Pathway: Implications for Colon Carcinogenesis

We report that deoxycholate (DOC), a hydrophobic bile acid associated with a high-fat diet, activates the autophagic pathway in non-cancer colon epithelial cells (NCM-460), and that this activation contributes to cell survival. The DOC-induced increase in autophagy was documented by an increase in...

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Bibliographic Details
Main Authors: Claire M. Payne, Cheray Crowley-Skillicorn, Hana Holubec, Katerina Dvorak, Carol Bernstein, Mary Pat Moyer, Harinder Garewal, Harris Bernstein
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:Journal of Toxicology
Online Access:http://dx.doi.org/10.1155/2009/785907

Internet

http://dx.doi.org/10.1155/2009/785907

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