Cardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in chagas disease pathogenesis.

Cardiac-oxidized antigens are targets of immune recognition by antibodies and potential molecular determinants in chagas disease pathogenesis.

Trypanosoma cruzi elicits reactive oxygen species (ROS) of inflammatory and mitochondrial origin in infected hosts. In this study, we examined ROS-induced oxidative modifications in the heart and determined whether the resultant oxidized cardiac proteins are targets of immune response and of patholo...

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Bibliographic Details
Main Authors: Monisha Dhiman, Maria Paola Zago, Sonia Nunez, Alejandro Amoroso, Hugo Rementeria, Pierre Dousset, Federico Nunez Burgos, Nisha Jain Garg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3251564?pdf=render

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http://europepmc.org/articles/PMC3251564?pdf=render

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