Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells

Hematopoietic stem cells (HSCs) reside within a specialized niche where interactions with vasculature, osteoblasts, and stromal components regulate their self-renewal and differentiation. Little is known about bone marrow niche formation or the role of its cellular components in HSC development; the...

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Bibliographic Details
Main Authors: Süleyman Coşkun, Hsu Chao, Hema Vasavada, Kartoosh Heydari, Naomi Gonzales, Xin Zhou, Benoit de Crombrugghe, Karen K. Hirschi
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714007815