Pharmacological Regulation of Tumor Hypoxia in Model Murine Tumors and Spontaneous Canine Tumors

Pharmacological Regulation of Tumor Hypoxia in Model Murine Tumors and Spontaneous Canine Tumors

Background: Hypoxia is found in many solid tumors and is associated with increased disease aggressiveness and resistance to therapy. Reducing oxygen demand by targeting mitochondrial oxidative metabolism is an emerging concept in translational cancer research aimed at reducing hypoxia. We have shown...

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Bibliographic Details
Main Authors: Martin Benej, Jinghai Wu, McKenzie Kreamer, Martin Kery, Sergio Corrales-Guerrero, Ioanna Papandreou, Terence M. Williams, Zihai Li, Edward E. Graves, Laura E. Selmic, Nicholas C. Denko
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
tumor microenvironment
hypoxia
mitochondria
resistance
papaverine
metabolism
Online Access:https://www.mdpi.com/2072-6694/13/7/1696

Internet

https://www.mdpi.com/2072-6694/13/7/1696

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