CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells

CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells

The p110β isoform of PI3K is preferentially activated in many tumors deficient in the phosphatase and tensin homolog (PTEN). However, the mechanism(s) linking PTEN loss to p110β activation remain(s) mysterious. Here, we identify CRKL as a member of the class of PI3Kβ-interacting proteins. Silencing...

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Bibliographic Details
Main Authors: Jing Zhang, Xueliang Gao, Fabienne Schmit, Guillaume Adelmant, Michael J. Eck, Jarrod A. Marto, Jean J. Zhao, Thomas M. Roberts
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
PI3K
p110β
CRKL
Src
p130Cas
PTEN
protein interaction
cancer
proliferation
signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717308859

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http://www.sciencedirect.com/science/article/pii/S2211124717308859

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