CD28 Autonomous Signaling Orchestrates IL-22 Expression and IL-22-Regulated Epithelial Barrier Functions in Human T Lymphocytes

CD28 Autonomous Signaling Orchestrates IL-22 Expression and IL-22-Regulated Epithelial Barrier Functions in Human T Lymphocytes

IL-22 is a member of the IL-10 cytokine family involved in host protection against extracellular pathogens, by promoting epithelial cell regeneration and barrier functions. Dysregulation of IL-22 production has also frequently been observed in acute respiratory distress syndrome (ARDS) and several c...

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Bibliographic Details
Main Authors: Martina Kunkl, Carola Amormino, Simone Frascolla, Manolo Sambucci, Marco De Bardi, Silvana Caristi, Stefano Arcieri, Luca Battistini, Loretta Tuosto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
CD28
IL-22
epithelial cell
T cell
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.590964/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.590964/full

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