Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide

Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide

Gene knockout and knockdown strategies have been immensely successful probes of gene function, but small molecule inhibitors (SMIs) of gene products allow much greater time resolution and are particularly useful when the targets are essential for cell replication or survival. SMIs also serve as lead...

Full description

Bibliographic Details
Main Authors: Nathan A. Snyder, Adam Kim, Louis Kester, Andrew N. Gale, Christian Studer, Dominic Hoepfner, Silvio Roggo, Stephen B. Helliwell, Kyle W. Cunningham
Format: Article
Language:English
Published: Oxford University Press 2019-03-01
Series:G3: Genes, Genomes, Genetics
Subjects:
auxin
auxin inducible degron
functional genomics
glycosylation
Golgi
rapamycin
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200748

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200748

Similar Items