Downregulation of p53 by Insufficient CTCF in CD4+ T Cells Is an Important Factor Inducing Acute Graft-Versus-Host Disease

Downregulation of p53 by Insufficient CTCF in CD4+ T Cells Is an Important Factor Inducing Acute Graft-Versus-Host Disease

Recent evidence indicates that p53 plays a protective role against various systemic autoimmune diseases by suppressing pro-inflammatory cytokine production and reducing the number of pathogenic T cells. However, whether abnormal p53 expression participates in the development of acute graft-versus-ho...

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Bibliographic Details
Main Authors: Juan Hua, Yan Chen, Bin Fu, Xu Chen, Xue-jun Xu, Shuang-Hui Yang, Cong Chen, Ya-jing Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
aGVHD
CD4+ T cell
p53
CTCF
P300
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.568637/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.568637/full

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