Methyl-CpG binding protein 2 (Mecp2) Regulates Sensory Function through Sema5b and Robo2

Methyl-CpG binding protein 2 (Mecp2) Regulates Sensory Function through Sema5b and Robo2

Mutations in the gene encoding the MECP2 underlies Rett syndrome, a neurodevelopmental disorder in young females. Although reduced pain sensitivity in Rett syndrome patients and in partial MeCP2 deficient mice had been reported, these previous studies focused predominantly on motor impairments. Ther...

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Bibliographic Details
Main Authors: Wan Ying eLeong, Zhi Hao eLim, Vladimir eKorzh, Thomas ePIETRI, Eyleen L Goh
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Trigeminal Ganglion
MeCP2
neurodevelopmental disorder
Rett Syndrome (RTT)
Axon guidance cues
Sensory functions
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00481/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00481/full

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