Distinct Dopamine D<sub>2</sub> Receptor Antagonists Differentially Impact D<sub>2</sub> Receptor Oligomerization

Distinct Dopamine D<sub>2</sub> Receptor Antagonists Differentially Impact D<sub>2</sub> Receptor Oligomerization

Dopamine D<sub>2</sub> receptors (D<sub>2</sub>R) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of schizophrenia. Pharmacological targeting and modulation of the equilibrium of these receptor hom...

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Bibliographic Details
Main Authors: Elise Wouters, Adrián Ricarte Marín, James Andrew Rupert Dalton, Jesús Giraldo, Christophe Stove
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
G protein-coupled receptor (GPCR)
dimerization
oligomerization
protein complementation assay
NanoLuc binary technology (NanoBiT)
dopamine D<sub>2</sub> receptor
Online Access:https://www.mdpi.com/1422-0067/20/7/1686

Internet

https://www.mdpi.com/1422-0067/20/7/1686

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