Protection of the Geum japonicum Thunb. var. chinense extracts against oxygen-glucose deprivation and re-oxygenation induced astrocytes injury via BDNF/PI3K/Akt/CREB pathway

Protection of the Geum japonicum Thunb. var. chinense extracts against oxygen-glucose deprivation and re-oxygenation induced astrocytes injury via BDNF/PI3K/Akt/CREB pathway

Geum japonicum Tunb. var. chinense (GJ) is a traditional Chinese medicine usually used for the alleviation of dizziness and headache. Previous studies have reported that the GJ extracts could alleviate cerebral I/R injury by reducing apoptosis in vivo. To further elucidate the positive role and unde...

Full description

Bibliographic Details
Main Authors:	Lipeng Du, Zhigang Mei, Yaguang Huang, Wei Tao, Kai Wang, Weifeng Huang, Huajun Zhou, Zhitao Feng
Format:	Article
Language:	English
Published:	Elsevier 2020-07-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Geum japonicum Tunb. var. chinense (GJ) extracts Cerebral ischemia/reperfusion (I/R) injury Oxygen-glucose deprivation and re-oxygenation (OGD/R) Astrocytes Apoptosis BDNF/PI3K/Akt/CREB pathway
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332220303152

Similar Items

Administration of Asian Herb Bennet (<i>Geum japonicum</i>) Extract Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone.
by: Dong Wook Lim, et al.
Published: (2019-11-01)

DEPENDENCE OF VITAMIN CONTENT IN THE GEUM URBANUM AND GEUM RIVALE (GEUM, ROSACEAE) ORGANS ON THE RHYTHM OF SEASONAL DEVELOPMENT
by: T. V. Burchenko
Published: (2017-07-01)

Quantification of sucrose in the root of Geum iranicum Khatamsaz
by: Somayeh Shahani, et al.
Published: (2015-09-01)

Antimicrobial Activity of Total Extract and Fractions of Geum kokanicum
by: HR Monsef - Esfahani, et al.
Published: (2009-05-01)

Antinociceptive and Anti-Inflammatory Effects of Geum iranicum Khatamsaz Methanol Extract in Mice
by: Nematollah Ahangar, et al.
Published: (2019-07-01)

SIRT1 Protects Against Apoptosis by Promoting Autophagy in the Oxygen Glucose Deprivation/Reperfusion-Induced Injury
by: Qiannan Ren, et al.
Published: (2019-12-01)

Comparative leaf and petiole anatomy and micro morphology of the genus Geum (Rosaceae) from Iran
by: Marzieh faghir, et al.
Published: (2017-05-01)

Aliskiren Improves Ischemia- and Oxygen Glucose Deprivation-Induced Cardiac Injury through Activation of Autophagy and AMP-Activated Protein Kinase
by: Ming-Hsien Chiang, et al.
Published: (2017-11-01)

DRAM1 Protects Neuroblastoma Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Injury via Autophagy
by: Mengqiang Yu, et al.
Published: (2014-10-01)

LncRNA FGD5-AS1 acts as a competing endogenous RNA for miRNA-223 to lessen oxygen-glucose deprivation and simulated reperfusion (OGD/R)-induced neurons injury
by: Xue-Qiang Zhang, et al.
Published: (2019-12-01)

Distribution and variability of the Balkan endemic Geum bulgaricum (Rosaceae) - a species of European concern
by: Dmitar Lakušić, et al.
Published: (2018-02-01)

Application of the Principle of No Man,s Land and Britain,s Justification in Occupying Iranian Islands of Tunb and Abu Musa in 1903 and its Consequences
by: Naqi Tabarsa
Published: (2005-05-01)

CHEMICAL CONSTITUENTS OF GEUM RIVALE L. AND THEIR BIOLOGICAL ACTIVITY
by: Anastasia A. Orlova, et al.
Published: (2020-10-01)

Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen–Glucose Deprivation/Reperfusion
by: Shuangxi Liu, et al.
Published: (2016-10-01)

The Antiapoptosis Effect of Geum japonicum Thunb. var. chinense Extracts on Cerebral Ischemia Reperfusion Injury via PI3K/Akt Pathway
by: Bingjin Ou, et al.
Published: (2018-01-01)

Kalirin-7 plays the neuroprotective role in Neuro-2A cells injured by oxygen-glucose deprivation and reperfusion through Rac1 activation
by: Jian Xu, et al.
Published: (2018-10-01)

Ciliary Neurotrophic Factor (CNTF) Protects Myocardial Cells from Oxygen Glucose Deprivation (OGD)/Re-Oxygenation via Activation of Akt-Nrf2 Signaling
by: Koulong Zheng, et al.
Published: (2018-11-01)

Thymosin β4 prevents oxygen-glucose deprivation/reperfusion-induced injury in rat cortical neurons
by: Zhang Z, et al.
Published: (2019-08-01)

Gut microbiota signatures in Schistosoma japonicum infection-induced liver cirrhosis patients: a case–control study
by: Qi-Feng Gui, et al.
Published: (2021-03-01)

Artemether confers neuroprotection on cerebral ischemic injury through stimulation of the Erk1/2-P90rsk-CREB signaling pathway
by: Shuai Li, et al.
Published: (2021-10-01)

HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury
by: Yanan Zhang, et al.
Published: (2019-12-01)

The Detection of Morphological Variation across Time in Two Roan Mountain Endemics: <em>Geum radiatum</em> and <em>Houstonia montana</em>.
by: Medford, Dalenia
Published: (2001)

miRNA-7a-2-3p Inhibits Neuronal Apoptosis in Oxygen-Glucose Deprivation (OGD) Model
by: Zi-Bin Zhang, et al.
Published: (2019-01-01)

Novel Microsatellite Markers for the High-Alpine <i>Geum reptans</i> (Rosaceae)
by: Elena Hamann, et al.
Published: (2014-06-01)

In vivo assessment of acute and subacute toxicity of ethyl acetate extract from aerial parts of Geum urbanum L
by: Lyudmila Dimitrova, et al.
Published: (2021-01-01)

miR-339 Promotes Hypoxia-Induced Neuronal Apoptosis and Impairs Cell Viability by Targeting FGF9/CACNG2 and Mediating MAPK Pathway in Ischemic Stroke
by: Xiao-Zeng Gao, et al.
Published: (2020-06-01)

Phylogeny and Character Evolution of the Genus Geum L. (Family Rosaceae) from Iran: Evidence from Analyses of Plastid and Nuclear DNA Sequences
by: Marzieh Beygom Faghir, et al.
Published: (2018-08-01)

Protein O-GlcNAcylation alleviates small intestinal injury induced by ischemia-reperfusion and oxygen-glucose deprivation
by: Ruochen Cong, et al.
Published: (2021-06-01)

Protection against Oxygen-Glucose Deprivation/Reperfusion Injury in Cortical Neurons by Combining Omega-3 Polyunsaturated Acid with Lyciumbarbarum Polysaccharide
by: Zhe Shi, et al.
Published: (2016-01-01)

Crocin regulates the proliferation and migration of neural stem cells after cerebral ischemia by activating the Notch1 pathway
by: Baizhu An, et al.
Published: (2020-10-01)

Antimicrobial and antioxidant potential of different solvent extracts of the medicinal plant Geum urbanum L.
by: Lyudmila Dimitrova, et al.
Published: (2017-11-01)

Liraglutide exhibits anti-inflammatory activity through the activation of the PKA/CREB pathway
by: Li Wang, et al.
Published: (2019-10-01)

Crosstalk between stressed brain cells: direct and indirect effects of ischemia and aglycemia on microglia
by: Monika Rabenstein, et al.
Published: (2020-01-01)

Oxidative Stress Underlies the Ischemia/Reperfusion-Induced Internalization and Degradation of AMPA Receptors
by: Lindsay M. Achzet, et al.
Published: (2021-01-01)

CREB Negatively Regulates IGF2R Gene Expression and Downstream Pathways to Inhibit Hypoxia-Induced H9c2 Cardiomyoblast Cell Death
by: Wei-Kung Chen, et al.
Published: (2015-11-01)

Hypericum japonicum Thunb. ex Murray: Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics of an Important Herbal Medicine
by: Lin-Sheng Liu, et al.
Published: (2014-07-01)

Water Quality Assessment of 14 Reservoirs in Geum River Basin Using Multivariate Statistical Analysis
by: Jin Ho Kim, et al.
Published: (2021-07-01)

RNA Binding Protein Motif 3 Inhibits Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis Through Promoting Stress Granules Formation in PC12 Cells and Rat Primary Cortical Neurons
by: Wenwen Si, et al.
Published: (2020-09-01)

Hyperjaponol H, A New Bioactive Filicinic Acid-Based Meroterpenoid from Hypericum japonicum Thunb. ex Murray
by: Rongrong Wu, et al.
Published: (2018-03-01)

Antihyperlipidemic activity of Allium chinense bulbs
by: Yung-Pin Lin, et al.
Published: (2016-07-01)