A Novel Cecropin-LL37 Hybrid Peptide Protects Mice Against EHEC Infection-Mediated Changes in Gut Microbiota, Intestinal Inflammation, and Impairment of Mucosal Barrier Functions

A Novel Cecropin-LL37 Hybrid Peptide Protects Mice Against EHEC Infection-Mediated Changes in Gut Microbiota, Intestinal Inflammation, and Impairment of Mucosal Barrier Functions

Intestinal inflammation can cause impaired epithelial barrier function and disrupt immune homeostasis, which increases the risks of developing many highly fatal diseases. Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes intestinal infections worldwide and is a major pathogen that induces int...

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Bibliographic Details
Main Authors: Xubiao Wei, Lulu Zhang, Rijun Zhang, Matthew Koci, Dayong Si, Baseer Ahmad, Junhao Cheng, Junyong Wang, Maierhaba Aihemaiti, Manyi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
enrofloxacin
Escherichia coli
hybrid peptide
inflammation
microflora
mucosal barrier
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01361/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01361/full

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