4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation.

4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation.

Recent studies have proposed that n-3 polyunsaturated fatty acids (n-3 PUFAs) have direct antioxidant and anti-inflammatory effects in vascular tissue, explaining their cardioprotective effects. However, the molecular mechanisms are not yet fully understood. We tested whether n-3 PUFAs showed antiox...

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Bibliographic Details
Main Authors: Atsushi Ishikado, Katsutaro Morino, Yoshihiko Nishio, Fumiyuki Nakagawa, Atsushi Mukose, Yoko Sono, Nagisa Yoshioka, Keiko Kondo, Osamu Sekine, Takeshi Yoshizaki, Satoshi Ugi, Takashi Uzu, Hiromichi Kawai, Taketoshi Makino, Tomio Okamura, Masayuki Yamamoto, Atsunori Kashiwagi, Hiroshi Maegawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3720569?pdf=render

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http://europepmc.org/articles/PMC3720569?pdf=render

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