Autophagic Upregulation Is Cytoprotective in Ischemia/Reperfusion-Injured Retina and Retinal Progenitor Cells

Autophagic Upregulation Is Cytoprotective in Ischemia/Reperfusion-Injured Retina and Retinal Progenitor Cells

The cytoprotective versus cytotoxic role of macroautophagy in ocular ischemia/reperfusion injuries remains controversial and its effects under hyperglycemia are unclear. We investigated the involvement of autophagy in in vitro and in vivo normoglycemic and hyperglycemic models of retinal ischemia/re...

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Bibliographic Details
Main Authors: Larissa Ho Ching Tang, Frederic Khe Cheong Fung, Angela Ka Wai Lai, Ian Yat Hin Wong, Kendrick Co Shih, Amy Cheuk Yin Lo
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
macroautophagy
hypoxia
autophagy inhibitors
LC3
LAMP1
NH<sub>4</sub>Cl
Online Access:https://www.mdpi.com/1422-0067/22/16/8446

Internet

https://www.mdpi.com/1422-0067/22/16/8446

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