Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic application

Determination of nimodipine in plasma by HPLC-MS/MS and pharmacokinetic application

To develop and validate a rapid, specific and highly sensitive method to quantify nimodipine in human plasma using dibucaine as the internal standard (IS). The analyte and IS were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1 v/v). The chromatographic sepa...

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Bibliographic Details
Main Authors: Demétrius Fernandes do Nascimento, Manoel Odorico de Moraes, Fernando Antônio Frota Bezerra, Andréa Vieira Pontes, Célia Regina Amaral Uchoa, Renata Amaral de Moraes, Ismenia Osório Leite, Gilmara Silva de Melo Santana, Ana Paula Macedo Santana, Ana Lourdes Almeida e Silva Leite, José Pedrazzoli Júnior, Maria Elisabete Amaral de Moraes
Format: Article
Language:English
Published: Universidade de São Paulo 2010-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Nimodipino
Farmacocinética
Nimodipine
Pharmacokinetics
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400008

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400008

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