Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

Thermo-Responsive PLGA-PEG-PLGA Hydrogels as Novel Injectable Platforms for Neuroprotective Combined Therapies in the Treatment of Retinal Degenerative Diseases

The present study aims to develop a thermo-responsive-injectable hydrogel (HyG) based on PLGA-PEG-PLGA (PLGA = poly-(DL-lactic acid co-glycolic acid); PEG = polyethylene glycol) to deliver neuroprotective agents to the retina over time. Two PLGA-PEG PLGA copolymers with different PEG:LA:GA ratios (1...

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Bibliographic Details
Main Authors: José Javier López-Cano, Sigen A., Vanessa Andrés-Guerrero, Hongyun Tai, Irene Bravo-Osuna, Irene Teresa Molina-Martínez, Wenxin Wang, Rocío Herrero-Vanrell
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
PLGA-PEG-PLGA
thermo-responsive hydrogel
micelles
neurodegenerative diseases
intravitreal drug delivery
oxidative stress
Online Access:https://www.mdpi.com/1999-4923/13/2/234

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https://www.mdpi.com/1999-4923/13/2/234

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