Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer

Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer

Abstract Background Chronic angiogenesis is a hallmark of most tumors and takes place in a hostile tumor microenvironment (TME) characterized by hypoxia, low nutrient and glucose levels, elevated lactate and low pH. Despite this, most studies addressing angiogenic signaling use hypoxia as a proxy fo...

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Bibliographic Details
Main Authors: A. K. Pedersen, J. Mendes Lopes de Melo, N. Mørup, K. Tritsaris, S. F. Pedersen
Format: Article
Language:English
Published: BMC 2017-08-01
Series:BMC Cancer
Subjects:
Cancer
Angiogenesis
VEGF
Signaling
Acid–base transport
pH regulation
Online Access:http://link.springer.com/article/10.1186/s12885-017-3532-x

Internet

http://link.springer.com/article/10.1186/s12885-017-3532-x

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