Potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting efflux transporter P-glycoprotein

Wutou-Gancao herb-pair is extensively used to attenuate the toxicity and enhance the efficacy of aconite. In this study, potential synergic mechanism of the herb pair was investigated by utilizing multiple approaches. In silico and in vitro Caco-2 cell models were applied to study the potential bind...

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Bibliographic Details
Main Authors: Yufei He, Zihong Wei, Ying Xie, Xiulin Yi, Yong Zeng, Yazhuo Li, Changxiao Liu
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Journal of Pharmaceutical Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177919303223