Is Oxidative Stress the Link Between Cerebral Small Vessel Disease, Sleep Disruption, and Oligodendrocyte Dysfunction in the Onset of Alzheimer’s Disease?

Is Oxidative Stress the Link Between Cerebral Small Vessel Disease, Sleep Disruption, and Oligodendrocyte Dysfunction in the Onset of Alzheimer’s Disease?

Oxidative stress is an early occurrence in the development of Alzheimer’s disease (AD) and one of its proposed etiologic hypotheses. There is sufficient experimental evidence supporting the theory that impaired antioxidant enzymatic activity and increased formation of reactive oxygen species (ROS) t...

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Bibliographic Details
Main Authors: Ana Lloret, Daniel Esteve, Maria Angeles Lloret, Paloma Monllor, Begoña López, José Luis León, Ana Cervera-Ferri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
demyelination
sleep dysfunction
blood-brain barrier permeability
ApoE4 and AD risk
vessel dysfunction
oligodendrocyte precursor cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.708061/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.708061/full

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