Development of a Bioluminescent BRCA1-Deficient Xenograft Model of Disseminated, High-Grade Serous Ovarian Cancer

Development of a Bioluminescent BRCA1-Deficient Xenograft Model of Disseminated, High-Grade Serous Ovarian Cancer

Successful translation of preclinical data relies on valid and comprehensive animal models. While high-grade serous ovarian cancer (HGSOC) is the most prevalent subtype, the most commonly used ovarian cancer cell lines are not representative of HGSOC. In addition, 50% of ovarian cancer patients pres...

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Bibliographic Details
Main Authors: Yen Ting Shen, Lucy Wang, James C. Evans, Christine Allen, Micheline Piquette-Miller
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
BRCA-deficiency
bioluminescent imaging
ovarian cancer
xenograft
metastasis
ascites
intraperitoneal
carboplatin
high-grade serous
Online Access:https://www.mdpi.com/1422-0067/20/10/2498

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https://www.mdpi.com/1422-0067/20/10/2498

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