X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells

X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells

Abstract Background Disabled-2 (Dab2) is known as a tumor suppressor as well as a Wnt pathway inhibitor. We previously reported that Dab2 was down-regulated due to gene promoter hypermethylation in lung cancer. Here, we aim to study if X-ray irradiation can induce de-methylation of the Dab2 gene and...

Full description

Bibliographic Details
Main Authors: Shuang Ma, Wan-Lin Zhang, Bruce D. Leckey, Hong-Tao Xu, Lian-He Yang, Endi Wang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Disabled-2
Lung cancer
Wnt pathway
Radiotherapy
Radiosensitivity
Online Access:http://link.springer.com/article/10.1186/s13046-018-1000-3

Internet

http://link.springer.com/article/10.1186/s13046-018-1000-3

Similar Items