Biological and clinical implications of cancer stem cells in primary brain tumors

Biological and clinical implications of cancer stem cells in primary brain tumors

Despite therapeutic advances, glioblastoma multiforme (GBM) remains a lethal disease. The infiltrative nature of this disease and the presence of a cellular population resistant to current medical treatments account for the poor prognosis of these patients. Growing evidence indicates the existence o...

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Bibliographic Details
Main Authors:	Marcello eMaugeri-Saccà, Simona edi Martino, Ruggero eDe Maria
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-01-01
Series:	Frontiers in Oncology
Subjects:	hypoxia cancer stem cells Glioblastoma Multiforme chemo-radioresistance canonical pathway inhibitors self-renewal pathway inhibitors
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00006/full

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